Cagrilintide 10mg

Cagrilintide – Long-Acting Amylin Receptor Agonist (Colombia)

Cagrilintide is a next-generation, long-acting amylin analogue designed to activate both amylin and calcitonin-family receptors. It belongs to the DACRA class (dual amylin and calcitonin receptor agonists), a category of advanced metabolic peptides under active investigation for body-weight and energy-balance research :contentReference[oaicite:0]{index=0}. Poly Biotech supplies Cagrilintide as a high-purity lyophilized peptide with controlled manufacturing and local availability for research programs in Colombia.

Product Overview

Cagrilintide is a 37–amino acid synthetic analogue of human amylin with strategic amino acid substitutions and N-terminal lipidation to enhance stability, receptor affinity, and half-life :contentReference[oaicite:1]{index=1}. By acting as a dual agonist at amylin receptors (AMY1/2/3) and calcitonin receptors (CTR), it enables multiplexed modulation of satiety and gastric motility pathways in experimental models :contentReference[oaicite:2]{index=2}. Poly Biotech maintains Cagrilintide in local Medellín inventory to support Colombian labs and clinics working with advanced metabolic peptides.

Key Features

• Long-acting amylin analogue in lyophilized powder form
• Engineered dual agonist activity at amylin and calcitonin receptors (DACRA class)
• High-purity synthesis with analytical quality control
  
• Local inventory in Colombia for faster delivery across Colombia

Specifications

• Peptide: Cagrilintide acetate (AM833 / NNC0174-0833)
• Content: Lyophilized peptide powder per vial (typically formatted for 5–10mg fills)
• Molecular formula: C₁₉₄H₃₁₂N₅₄O₅₉S₂ (approximate) :contentReference[oaicite:3]{index=3}
• Molecular weight: ~4,400 Da :contentReference[oaicite:4]{index=4}
• Structure: 37–amino acid amylin analogue with N-terminal lipid modification
• Appearance: White to off-white lyophilized powder
• Storage: Refrigerated at 2–8°C; long-term stability improved under frozen storage
• Country of distribution: Colombia (stock in Medellín)

Mechanistic Background

Cagrilintide engages amylin receptors (AMY1R, AMY2R, AMY3R) formed by calcitonin receptor (CTR) and receptor-activity–modifying proteins (RAMPs), as well as CTR itself, to deliver dual agonism at calcitonin-family receptors :contentReference[oaicite:5]{index=5}. Structural and pharmacological studies show that this dual activation leads to robust modulation of appetite-regulating and gastric-emptying pathways in preclinical and clinical research settings :contentReference[oaicite:6]{index=6}.

Reconstitution

Cagrilintide can be reconstituted using bacteriostatic water or another suitable sterile laboratory diluent, according to the laboratory’s internal SOPs. Final concentrations, dilution schemes, and handling steps should be defined by the responsible research team to align with their specific study design.

Applications in Research

• Advanced metabolic and body-weight regulation models
• Amylin and calcitonin receptor signalling studies
• Combination-therapy research alongside GLP-1 receptor agonists :contentReference[oaicite:7]{index=7}
• Mechanistic work on gastric emptying, satiety signalling, and energy balance :contentReference[oaicite:8]{index=8}

Why Poly Biotech

• Focused on supplying high-end metabolic and peptide tools within Colombia
• Local warehousing in Medellín to reduce lead times and import complexity
• Consistent purity standards backed by analytical testing
• Support for clinics and laboratories designing next-generation metabolic research
• Tiered pricing options for programs that require recurring or high-volume Cagrilintide supply

Wholesale Availability

Cagrilintide is available for institutional and clinic-level orders in flexible vial counts, including small pilot batches and larger program-scale volumes. Colombian labs and clinics can work directly with Poly Biotech to plan recurring shipments, integrate Cagrilintide into broader peptide portfolios, and align inventory with long-term study timelines.