What is TB-500?
TB-500 is the synthetic version of a peptide fragment from thymosin beta-4, a naturally occurring protein found in nearly all human and animal cells. Research suggests TB-500 may play a role in tissue regeneration, angiogenesis (blood vessel growth), and inflammation control. Because of these properties, it is widely studied in the context of recovery, repair, and healing.
Quick Facts
| CAS | 77591-33-4 |
| Formula / MW | C212H350N56O78S · ~4963 g/mol |
| Form | Lyophilized peptide powder |
| Storage (powder) | –20 °C (long-term) |
| Storage (reconstituted) | 2–8 °C; stable 20–30 days |
How Does TB-500 Work?
TB-500 is a peptide fragment of thymosin beta-4, which is involved in cellular migration, wound healing, and blood vessel formation. Research suggests TB-500 may:
- Promote angiogenesis, increasing blood flow to injured tissue
- Enhance cell migration to accelerate wound closure
- Reduce inflammation in models of injury
- Support muscle, tendon, and ligament recovery
What Research Has Explored
- Muscle and tendon recovery: animal models show faster healing and less scar tissue
- Wound repair: improved angiogenesis and tissue remodeling
- Eye injuries: investigated for corneal healing and repair
- Anti-inflammatory activity: modulation of immune cell response
Reported Side Effects in Research
Preclinical research suggests TB-500 is generally well tolerated, with mild side effects such as redness at injection sites or temporary fatigue. Long-term human safety data are limited, and it remains for research only. TB-500 is not WADA-approved and is prohibited in competitive athletics.
Interesting Notes & Practical Tips
- Pairing with BPC-157: TB-500 is often studied alongside BPC-157 for combined healing effects, sometimes referred to as the “ultimate recovery stack” and/or "Wolverine Stack". Buy BPC-157/TB-500 Blend Colombia
- Rapid spread: Some researchers note TB-500 disperses quickly after administration, potentially explaining its systemic effects.
- Equine research roots: TB-500 was originally explored in veterinary research for performance horses before gaining popularity in broader peptide studies.
- Cosmetic crossover: Early studies suggest possible roles in hair growth and skin regeneration, though evidence is limited.
Lifestyle Tips (General Research Context)
Research on recovery peptides consistently shows better results when combined with good fundamentals: balanced diet rich in protein, hydration, mobility work, and consistent sleep. These habits amplify peptide-based recovery protocols in experimental contexts.
Reconstitution Guide (10 mg Vial)
- Add 2 mL bacteriostatic water to your 10 mg vial.
- Final concentration = 5 mg/mL.
- On a 100-unit insulin syringe: 1 mg = 20 units.
| Dose | Volume (mL) | Syringe (units) |
|---|---|---|
| 2 mg | 0.40 mL | 40 units |
| 5 mg | 1.00 mL | 100 units |
Refrigerate reconstituted vials at 2–8 °C and use within 20–30 days. Do not refreeze after mixing.
Example Research Dosing Protocols
While no standard human protocol exists, research designs often explore:
- Loading phase: 2–5 mg, 2–3 times weekly for 4–6 weeks
- Maintenance: 2–5 mg once weekly after initial phase
- Stacked with BPC-157: smaller doses of each compound, administered together
Values above are research examples from preclinical and anecdotal contexts. Human dosing is not established.
Handling & Storage
- Keep powder frozen at –20 °C until use.
- Refrigerate reconstituted vials at 2–8 °C.
- Always use sterile mixing and injection techniques.
Research & Sources
- Thymosin beta-4 in Wound Healing – PubMed
- TB-500 and Angiogenesis Research
- PubChem – Thymosin Beta-4
Explore More
• TB-500 10 mg - Product Page
• BPC-157 – Recovery Research Guide
• GHK-Cu - Research Guide
• Recovery & Vitality Collection
Disclaimer: For laboratory research use only. Not for human consumption, therapeutic, or diagnostic use. Follow local laws and regulations.
