What is GHK-Cu?
GHK-Cu (glycyl-L-histidyl-L-lysine copper) is a naturally occurring copper-binding peptide found in human plasma and tissues. It has been studied for its ability to stimulate collagen production, improve wound healing, and support skin regeneration. First identified in the 1970s, it remains one of the most widely researched cosmetic and regenerative peptides.
Quick Facts
| CAS | 49557-75-7 |
| Formula / MW | C14H24N6O4 · Cu · ~404.9 g/mol |
| Form | Lyophilized peptide powder (blue hue from copper) |
| Storage (powder) | –20 °C (long-term) |
| Storage (reconstituted) | 2–8 °C; stable 10–14 days |
How Does GHK-Cu Work?
GHK-Cu binds copper ions, a process essential for many enzymatic reactions in skin and connective tissue. Research shows it can:
- Stimulate collagen and elastin synthesis
- Promote angiogenesis (new blood vessel growth)
- Accelerate wound healing and tissue remodeling
- Reduce oxidative stress and inflammation
What Research Has Explored
- Cosmetic use: topical studies report improvements in skin elasticity, firmness, and wrinkle depth
- Wound healing: accelerated closure and better tissue quality in animal models
- Hair growth: pilot studies suggest stimulation of hair follicles
- Anti-inflammatory effects: modulation of genes linked to inflammation and tissue damage
Reported Side Effects in Research
GHK-Cu has generally been considered safe in preclinical and cosmetic studies. Reported mild effects include temporary redness or irritation at topical or injection sites. High systemic doses have not been well-studied, and safety beyond cosmetic concentrations is not established.
Interesting Notes & Practical Tips
- Blue color: Unlike most peptides, GHK-Cu has a distinct blue color due to its copper content - an easy authenticity check.
- Topical vs. injectable: Research has explored both. Topical creams showed visible skin improvements in just 8–12 weeks in some trials.
- Anti-aging gene switch: Gene expression studies suggest GHK-Cu can “reset” expression of hundreds of genes toward a more youthful profile.
- Combination use: Often studied with BPC-157 or TB-500 for enhanced healing, or with microneedling in cosmetic research.
- Hair growth: Some small trials reported regrowth when applied to the scalp, making it popular in cosmetic formulations.
Lifestyle Tips (General Research Context)
Research on skin and tissue recovery shows best outcomes when paired with healthy habits: balanced nutrition (especially protein and vitamin C for collagen), hydration, sleep, and avoiding smoking or excess UV exposure.
Reconstitution Guide (10 mg Vial)
- Add 2 mL bacteriostatic water to your 10 mg vial.
- Final concentration = 5 mg/mL.
- On a 100-unit insulin syringe: 1 mL = 100 units.
| Dose | Volume (mL) | Syringe (units) |
|---|---|---|
| 1 mg | 0.20 mL | 20 units |
| 2 mg | 0.40 mL | 40 units |
| 5 mg | 1.00 mL | 100 units |
Refrigerate reconstituted vials at 2–8 °C and use within 10–14 days. Do not refreeze after mixing.
Example Research Dosing Protocols
Research designs vary depending on the focus:
- Skin/cosmetic studies: topical or microinjection, typically small doses repeated over weeks
- Wound healing models: local injections near injury sites in animal studies
- Systemic research: doses less clearly defined; most research is cosmetic and localized
These protocols are drawn from cosmetic and preclinical studies. Human systemic dosing is not established.
Handling & Storage
- Use sterile technique and avoid contamination.
- Label vials clearly with date and concentration.
- Store powders at -20 °C; reconstituted at 2–8 °C.
Research & Sources
Explore More
• GHK-Cu 10 mg - Product Page
• BPC-157 - Recovery Research Guide
• Recovery & Vitality Collection
Disclaimer: For laboratory research use only. Not for human consumption, therapeutic, or diagnostic use. Follow local laws and regulations.
