Retatrutide - Research Dosing & Guide

What is Retatrutide?

Retatrutide is a triple-agonist peptide that activates GLP-1, GIP, and glucagon receptors. Because it acts on these three pathways at once, studies have explored its potential for weight loss, metabolic health, and blood sugar control. It builds on earlier incretin drugs:
• Semaglutide (GLP-1 only)
• Tirzepatide (GLP-1 + GIP)
• Retatrutide (GLP-1 + GIP + Glucagon)

Quick Facts

How Does It Work?

• GLP-1 receptor activation → slows digestion, reduces appetite, supports insulin release.
• GIP receptor activation → assists glucose control and fat metabolism.
• Glucagon receptor activation → increases energy expenditure and fat breakdown.

Together, these actions influence appetite, energy balance, and metabolism at the same time.

What Research Has Explored

• Weight management: significant body-weight reductions over weeks to months.
• Blood sugar: improved fasting glucose and HbA1c in type 2 diabetes trials.
• Metabolic health: supportive changes in appetite control and lipid profiles.

Note: Findings are from early-stage research and clinical trials. Retatrutide is not approved for treatment.

Commonly Reported Side Effects

• Nausea, vomiting, indigestion
• Constipation or diarrhea, abdominal discomfort
• Headache; dehydration if fluid intake is low

Tips: start low and increase slowly, eat smaller meals (avoid heavy/greasy foods), and drink enough water.

Contraindications (Do Not Use if)

• Pregnant or breastfeeding
• Personal/family history of thyroid cancer
• Severe gastrointestinal disease
• Advanced kidney or liver disease
• Known allergy/hypersensitivity to peptide products

Lifestyle Tips (General Research Context)

• Stay hydrated: drinking plenty of water reduces nausea, headaches, and constipation often reported in GLP-1 studies.
• Balanced diet: prioritize protein, fruits, and vegetables; avoid greasy meals which may worsen stomach upset.
• Exercise: combine strength training and cardio for better metabolic results and muscle preservation.
• Sleep: aim for 7–8 hours per night to support appetite regulation and recovery.

These are general health practices mentioned in research contexts. They are not medical advice.

Reconstitution Guide (10 mg Vial)

1. Add 2 mL (200 units) of bacteriostatic water to the 10 mg vial.
2. This yields a concentration of 5 mg/mL.
3. On a 100-unit insulin syringe: 1 mL = 100 units.

Store reconstituted vials in the refrigerator (2–8 °C). Use within 20–30 days. Keep powder frozen at –20 °C for long-term storage. Do not refreeze after mixing.

Example Research Dosing Schedule

Principle: start low and build slowly.

• Weeks 1–4: ~0.5–1 mg once weekly (10–20 units)
• Weeks 5–8: if tolerated, increase to 2 mg once weekly (40 units)
• Weeks 9–12: if needed and tolerated, consider 3–4 mg once weekly (60–80 units)

Keep the same day each week. Remain at each dose for ~4 weeks before increasing.

Handling & Storage

• Use sterile technique and alcohol-prepped stoppers.
• Avoid repeated freeze–thaw cycles.
• Label vials with mix date, concentration, and storage conditions.

Research Stacking Examples

• BPC-157 + TB-500: soft-tissue/joint support during weight loss phases.
• GHK-Cu: skin/collagen support while cutting.
• Glutathione: antioxidant and liver support.
• AOD-9604: complementary lipolysis pathway.

All stacking ideas are for laboratory exploration only.

Research & Sources

• NEJM 2023 - Retatrutide in Adults with Obesity
• ClinicalTrials.gov - Retatrutide Studies
• PubMed Search - Retatrutide

Explore More

• Retatrutide 10 mg - Product Page
• Metabolic Collection
• Recovery & Vitality Collection

Disclaimer: For laboratory research use only. Not for human consumption, therapeutic, or diagnostic use. Follow local laws and regulations.