Selank and Semax are two of the most widely studied neuropeptides in neurobiology and cognitive research. Developed from endogenous peptide fragments, both compounds have played important roles in research exploring neuroplasticity, behavior, stress response, memory formation, and adaptive regulation of neurotransmitters. In Colombia, these peptides have become increasingly relevant as laboratories and academic institutions expand their focus on advanced peptide signaling and cognitive science.
This article provides a detailed, research-focused comparison of Selank and Semax — covering their origins, biochemical properties, mechanisms explored in laboratory studies, pathway interactions, and typical applications in cognitive and behavioral research. No medical or therapeutic claims are made or implied.
Background and Development
Semax
Semax (MEHFPGP) is a synthetic analogue of the ACTH (adrenocorticotropic hormone) fragment ACTH 4–10. It was engineered to isolate the neuroactive properties of ACTH fragments without influencing adrenal hormone production. Semax has been studied for its potential role in modulating gene expression related to neurotrophic factors, neurotransmitter balance, and neural adaptation.
Additional reference: Semax – PubChem Database
Selank
Selank (TKPRPGP) is derived from tuftsin, a naturally occurring tetrapeptide involved in immune modulation. Researchers modified tuftsin’s structure to increase stability and extend its activity. Selank became a subject of interest in behavioral research for its interaction with the GABAergic system and its influence on stress-related pathways.
Additional reference: Selank – PubChem Database
Biochemical Properties
| Feature | Semax | Selank |
|---|---|---|
| Peptide Origin | ACTH 4–10 analogue | Tuftsin analogue |
| Sequence | MEHFPGP | TKPRPGP |
| Primary Research Focus | Neuroplasticity, learning, cognitive signaling | Behavior, stress response, GABA modulation |
| Molecular Stability | Moderate, stable in aqueous solution | Enhanced due to structural modifications |
| Typical Form | Lyophilized powder, 5 mg vial | Lyophilized powder, 5 mg vial |
Mechanisms Explored in Research
Semax Mechanisms
Laboratory research has shown Semax to influence several key pathways:
- Regulation of neurotrophic factors such as BDNF and NGF
- Modulation of dopaminergic and serotonergic systems in cognitive and emotional models
- Impact on gene expression related to synaptic plasticity and memory formation
- Neuroprotective-response signaling under oxidative or metabolic stress in cell and animal studies
Supporting literature: NCBI – Peptide-based neurotrophic modulation
Selank Mechanisms
Selank has been investigated most prominently in behavioral and stress-related studies. Results from laboratory models suggest:
- Modulation of the GABAergic system
- Influence on monoamine metabolism
- Regulation of neurochemical responses involved in stress, focus, and mood balance
- Potential immune-neuro interactions due to its tuftsin origin
Supporting literature: Selank Peptide Research Overview
Comparative Applications in Research
The following research areas commonly differentiate the two peptides:
Semax Research Applications
- Studies on learning and memory
- Synaptic plasticity and neuronal adaptation
- Behavioral models requiring increased cognitive load
- Comparative models with ACTH-derived peptides
Selank Research Applications
- Behavioral stress models
- GABAergic modulation studies
- Neuro-immune signaling research
- Comparative studies with tuftsin and ACTH fragments
Which Peptide Should Researchers Choose?
Because Selank and Semax influence different pathways, the choice depends entirely on research goals. Semax is often selected for cognitive or neuroplasticity-focused experiments, while Selank is generally preferred in stress-response, behavioral, and GABA-pathway research.
Many laboratories use both peptides in complementary study designs due to their distinct yet synergistic biochemical profiles.
External Resources for Further Research
- Semax – PubChem
- Selank – PubChem
- NCBI – National Center for Biotechnology Information
- NCBI PMC – Peer-Reviewed Studies
- Selank – Wikipedia
- Semax – Wikipedia
Selank and Semax in Colombia – Poly Biotech
Poly Biotech supplies high-purity Selank 5 mg and Semax 5 mg for research institutions, laboratories, and academic environments in Colombia. All products are shipped discreetly with nationwide delivery and are intended strictly for research use.
For research use only. Not for human consumption. No medical claims are made or implied.
