What is BPC-157?
BPC-157 (Body Protection Compound-157) is a synthetic 15-amino-acid peptide derived from a gastric protein fragment. It has been widely explored in preclinical research for tissue recovery, vascular support, and inflammation pathways. Human data remain limited.
Quick Facts
| CAS | 137525-51-0 |
| Sequence | Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val |
| Formula / MW | C62H98N16O22 · ~1419.5 g/mol |
| Appearance | White lyophilized powder |
| Storage (powder) | –20 °C (long-term) |
| Storage (reconstituted) | 2–8 °C; avoid repeated freeze–thaw |
How Does It Work? (Research Context)
- Angiogenesis & circulation: explored for supporting new blood vessel growth and tissue perfusion.
- Inflammation pathways: literature describes modulation of pro-/anti-inflammatory signals.
- Tissue repair models: animal studies report improved outcomes in tendon, ligament, muscle, bone, and GI mucosa.
Note: Findings above are from preclinical research; human evidence is sparse (e.g., a small pilot safety infusion).
What Research Has Explored
- Musculoskeletal recovery models (muscle, tendon, ligament, bone)
- Gastrointestinal mucosal protection and healing
- Vascular remodeling and nitric-oxide–related signaling
Regulatory Notes (Athletes & Safety)
WADA: BPC-157 is listed under S0: Non-approved substances on the World Anti-Doping Agency Prohibited List.
FDA (US): BPC-157 appears on the Category 2 bulks list for compounding, citing limited safety data and impurity/characterization risks.
Safety & Side Effects
Human safety data are limited. Reported effects in anecdotal contexts include digestive upset or headache; robust clinical profiles are lacking. Treat strictly as a research-only material. Athletes should avoid due to WADA status.
Interesting Notes & Practical Tips
- Oral activity? Some animal studies suggest BPC-157 may remain stable when taken orally, unusual for a peptide. This comes from its origin in gastric proteins, though human data is very limited.
- Nitric oxide link: Research connects BPC-157 to the NO pathway, with effects on blood pressure and circulation. This has made it popular in vascular recovery studies.
- Quality check: After mixing, your solution should be clear and colorless. Persistent cloudiness or flakes are red flags for poor quality.
- Popular pair: Often studied alongside TB-500 for “healing stacks.” Researchers note potential synergy between the two peptides.
- Global paradox: Even though BPC-157 is banned for athletes and flagged by regulators, it remains one of the most purchased peptides worldwide for recovery research.
Lifestyle Tips (General Research Context)
For recovery-focused projects, basic habits matter: stay well-hydrated, aim for adequate protein, keep regular resistance + light cardio sessions, and maintain 7–8 hours of sleep. These habits consistently support metabolic and tissue-repair goals in research settings.
Reconstitution Guide (10 mg Vial)
- Add 2 mL bacteriostatic water to your 10 mg vial.
- Final concentration = 5 mg/mL (i.e., 1 mL = 5 mg).
- On a 100-unit insulin syringe: 1 mL = 100 units.
| Amount | Volume (mL) | Syringe (units) |
|---|---|---|
| 250 mcg (0.25 mg) | 0.05 mL | 5 units |
| 500 mcg (0.5 mg) | 0.10 mL | 10 units |
| 1 mg | 0.20 mL | 20 units |
| 2 mg | 0.40 mL | 40 units |
After mixing, store at 2–8 °C and use within 20–30 days. Keep powder at –20 °C long-term. Do not refreeze after reconstitution.
Example Research Dosing Planning
Principle: start low and increase gradually, allowing time at each level to assess tolerance.
- Common lab planning uses small per-administration totals (e.g., 250–500 mcg), adjusted stepwise.
- Preclinical rodent models often use weight-based microgram dosing across 10–14 days; translate cautiously across species.
All values above are research context examples, not medical guidance.
Handling & Storage
- Use sterile technique and alcohol-prepped stoppers.
- Avoid repeated freeze–thaw cycles.
- Dispose of sharps and consumables safely.
Research & Sources
- HSS Journal 2025 - Systematic Review of BPC-157 in Orthopaedic Sports Medicine
- J Orthop Res 2010 - Ligament/Tendon Healing Model (Cerovecki et al.)
- PubChem - BPC-157 (sequence, identifiers)
- WADA 2025 Prohibited List - S0 Non-approved Substances (includes BPC-157)
- FDA - Category 2 Bulks (BPC-157 safety/impurity concerns)
- Pilot Safety Infusion (n=2 adults) - No acute adverse effects reported
Explore More
• BPC-157 10 mg - Product Page
• Recovery & Vitality Collection
Disclaimer: For laboratory research use only. Not for human consumption, therapeutic, or diagnostic use. Follow local laws and regulations.
